IRIS as a post-transplantation complication in primary immunodeficiency with disseminated M. avium.

Maura Manion,Dimana Dimitrova,Luxin Pei,Juan Gea-Banacloche,Adrian Zelazny,Andrea Lisco,Christa Zerbe,Alexandra F Freeman,Steven M Holland,Christopher G Kanakry,Jennifer A Kanakry,Irini Sereti

CLINICAL INFECTIOUS DISEASES（2020）

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摘要

Patients with primary immunodeficiencies undergoing allogeneic hematopoietic cell transplantation (HCT) for difficult-to-control infections can experience immune reconstitution inflammatory syndrome (IRIS) following engraftment. In 3 patients with post-HCT IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-specific immune responses and a concomitant rise in plasma inflammatory markers.

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关键词

immune reconstitution,bone marrow transplantation,primary immunodeficiency,Mycobacterium avium

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