Multi-Frequency Magnetic Particle Imaging enabled by a combined passive and active Drive Field Feed-Through Compensation Approach.

Purpose Magnetic particle imaging (MPI) allows fast imaging of the spatial distribution of superparamagnetic iron-oxide based nanoparticles (SPIONs). Recent research suggests that MPI furthermore promises in-vivo access to environmental parameters of SPIONs as temperature or viscosity. Various medical applications as nanomedicine, stem cell-based therapies or magnetic hyperthermia could benefit from in-vivo multiparameter estimation by MPI. One possible approach to get access to functional parameters is particle excitation at multiple frequencies. To enable the investigation of the mentioned approach, a novel MPI device capable of multifrequency excitation is needed. Methods MPI usually employs analog band-stop filters to cancel the drive field feed-through, which is magnitudes higher than the particle signal. To enable drive field frequency flexibility over a wide bandwidth, we propose a combined passive and active drive field feed-through compensation approach. This cancellation technique further allows the direct detection of the SPIONs' signal at the fundamental excitation frequency. Results A combined feed-through suppression of up to -125 dB is reported, which allows to adjust the drive field frequency from 500 Hz to 20 kHz. Initial spectroscopic measurements and images are shown that demonstrate the concept of multifrequency excitation and prove the imaging capability of the presented scanner. A mean signal-to-noise ratio (SNR) enhancement by the factor of 1.7 was shown when the first harmonic is used for measurement-based image reconstruction compared to when it is omitted. Conclusions In this paper, the first one-dimensional multifrequency magnetic particle imaging (mf-MPI) that features adjustable excitation frequencies from 500 Hz to 20 kHz is presented. The device will be used to study the principle of multiparameter estimation by employing multifrequency excitation.