Shear stress regulation of miR-93 and miR-484 maturation through nucleolin

Jiao Zhang
Jiao Zhang
Wei Sun
Wei Sun
Shanshan Chen
Shanshan Chen
Lili Chen
Lili Chen
Jun-Hui Liu
Jun-Hui Liu

Proceedings of the National Academy of Sciences of the United States of America, Volume 116, Issue 26, 2019, Pages 12974-12979.

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Keywords:
AMPKendothelial cellsmiRNAnucleolinshear stress

Abstract:

Pulsatile shear (PS) and oscillatory shear (OS) elicit distinct mechanotransduction signals that maintain endothelial homeostasis or induce endothelial dysfunction, respectively. A subset of microRNAs (miRs) in vascular endothelial cells (ECs) are differentially regulated by PS and OS, but the regulation of the miR processing and its impl...More

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