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First-Time-in-Human Study and Prediction of Early Bactericidal Activity for GSK3036656, a Potent Leucyl-tRNA Synthetase Inhibitor for Tuberculosis Treatment.

Antimicrobial Agents and Chemotherapy(2019)

Cited 54|Views40
Key words
EBA prediction,FTIH,GSK3036656,clinical trial simulations,dose escalation,dose rationale,food effect,pharmacokinetics,repeat dose,safety,single dose,tolerability,tuberculosis
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