Five year iron changes in relapsing-remitting multiple sclerosis deep gray matter compared to healthy controls.

•First 5-year study of Deep Gray Matter iron in relapsing-remitting MS & controls.•R2*, susceptibility and volumes were studied using bulk and regional analysis.•Bulk analysis detected significantly different thalamic shrinkage rates for MS.•Iron-specific regional analysis found significantly different iron decrease in MS.•No significantly different iron increase was found using regional analysis.