PPP1R3C mediates metformin-inhibited hepatic gluconeogenesis.

Xueying Ji,Shushu Wang,Hongju Tang,Yuqing Zhang,Feiye Zhou,Linlin Zhang,Qin Zhu,Kecheng Zhu,Qianqian Liu,Yun Liu,Xiao Wang,Libin Zhou

Metabolism（2019）

引用 22|浏览59

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摘要

•Metformin and AMPK activation decrease cAMP-stimulated hepatic PPP1R3C expression.•PPP1R3C overexpression antagonizes metformin-inhibited hepatic gluconeogenesis.•PPP1R3C knockdown inhibits hepatic gluconeogenesis and related gene expression.•PPP1R3C knockdown blocks cAMP-stimulated TORC2 dephosphorylation.•PPP1R3C knockdown alleviates hyperglycemia in db/db mice.

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关键词

cAMP,CREB,PKA,TORC2,AMPK,PEPCK,G6Pase,PPP1R3C,8-Br-cAMP,PTT,Fbpase,SIK2

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