Metabolic stress activates an ERK/hnRNPK/DDX3X pathway in pancreatic β cells.

Austin L Good,Matthew W Haemmerle,Alexis U Oguh,Nicolai M Doliba,Doris A Stoffers

Molecular Metabolism（2019）

引用 26|浏览12

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摘要

•A polyC motif is identified in the 3′UTRs of post-transcriptionally regulated genes.•hnRNPK mediates the post-transcriptional induction of JUND during metabolic stress.•hnRNPK is phosphorylated in β cells during metabolic stress.•MEK/ERK signaling is necessary and sufficient to activate hnRNPK/JUND.•DDX3X interacts with hnRNPK and regulates translation of JUND mRNA.

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关键词

RNA-Binding proteins,β cell,Stress,Translational regulation,Signaling

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