Two mutations in viral protein enhance the adaptation of waterfowl-origin H3N2 virus in murine model.

Zhijun Yu,Kaihui Cheng,Tiecheng Wang,Zhiguang Ren,Jiaqiang Wu,Hongbin He,Yuwei Gao

Virus Research（2019）

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摘要

•PB2-D701N and M1-M192V decrease the MLD50 of H3N2 virus in mammals.•PB2-D701N mutation enhance H3N2 virus replication in vitro and in vivo.•PB2-D701N mutation expand viral tissue tropism of H3N2 virus in mammals.

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关键词

H3N2,Avian influenza virus,Waterfowl,Mice,Pathogenesis

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