Increased intra-articular granzyme M may trigger local IFN-λ1/IL-29 response in rheumatoid arthritis.

Liling Shan,Lucas L van den Hoogen,Jan Meeldijk,Helena M Kok,Lieneke H Jongeneel,Marianne Boes,Mark H Wenink,C Erik Hack,Timothy R D J Radstake,Joel A G van Roon,Niels Bovenschen

Clinical and experimental rheumatology（2020）

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摘要

These data indicate that GrM levels are increased in RA synovial fluid and that GrM can stimulate proinflammatory IL-29 release from fibroblasts, suggesting a role of GrM in the pathogenesis of RA.

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关键词

rheumatoid arthritis,intra-articular

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