Structural Basis for Substrate Selectivity and Nucleophilic Substitution Mechanisms in Human Adenine Phosphoribosyltransferase Catalyzed Reaction

N. Mohammad Ozeir,Jessica Huyet,Marie-Claude Burgevin,Benoit Pinson,Francoise Chesney,Jean-Marc Remy,Abdul Rauf Siddiqi,Roland Lupoli,Grgory Pinon,Christelle Saint-Marc,Jean-Francois Gibert,Renaud Morales,Irene Ceballos-Picot,Robert Barouki,Bertrand Daignan-Fornier,Anne Olivier-Bandini,Franck Auge,Pierre Nioche

Journal of Biological Chemistry（2019）

引用 5|浏览36

关键词

enzyme mechanism,purine,protein structure,nucleoside,nucleotide biosynthesis,quantum chemistry,adenine,hypoxanthine,QM,MM calculation,forward and reverse reactions,nucleoside monophosphate

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