Comparative Analysis of Circulating Non-Coding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury.

In a comparative assessment of ncRNAs and protein biomarkers for myocardial injury, cMyC showed properties as the most sensitive cardiac biomarker while miRNAs emerged as promising candidates to integrate ncRNAs with protein biomarkers. Sensitivity of current miRNA detection is inferior to cardiac proteins but a multi-biomarker combination of muscle-enriched miRNAs with cMyC and hs-cTnT could open a new path of integrating complementary characteristics of different biomarker species.