In search of safe pain relief: The analgesic and anti-inflammatory activity of phytosteryl ibuprofenates.

M Elena Hernández-Flores,J Martín Torres-Valencia,Raquel Cariño-Cortés,Mario I Ortiz,Heraclio López-Ruiz,Susana Rojas-Lima,Carlos M Cerda-García-Rojas,Pedro Joseph-Nathan

Steroids（2019）

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摘要

•Phytosteryl ibuprofenates possess comparable activity than ibuprofen at the same mg/kg doses.•The new esters cause minimal gastric injury in comparison with free ibuprofen.•Acute toxicity in in vivo models suggests that phytosteryl ibuprofenates are safe for consumption.

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关键词

Phytosteryl (S)-ibuprofenates,Spectroscopy properties,In vivo pain models,Antinociception,Anti-inflammation,Gastric injury

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