CXCL1 promotes the proliferation of neural stem cells by stimulating the generation of reactive oxygen species in APP/PS1 mice.

Yu Shang,Li Tian, Tianjiao Chen,Xiaoying Liu,Jilin Zhang,Dongxin Liu,Jiayi Wei,Wengang Fang,Yuhua Chen,Deshu Shang

Biochemical and Biophysical Research Communications（2019）

引用 18|浏览28

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摘要

•Macrophages contribute to elevated levels of CXCL1 in APP/PS1 mice.•CXCL1 promotes proliferation of neural stem cells, inhibit its differentiation.•CXCL1 promotes production of reactive oxygens.

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关键词

CXCL1,Neural stem cells,Reactive oxygen species,APP/PS1 mice,NOX2,PI3K/Akt

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