A Multiple Dose Phase 1 Assessment of Rilpivirine Long-Acting in a Model of Pre-Exposure Prophylaxis against HIV.

Ross D Cranston,Charlene S Dezzutti,Aaron Siegel,Jarret Engstrom,Cory Shetler,Nicola Richardson-Harman,Kaleab Z Abebe,David Back,Laura Else,Deidre Egan,Saye Khoo,James E Egan,Ronald Stall,Peter Williams,Rhonda M Brand,Urvi M Parikh,Ian McGowan

AIDS research and human retroviruses（2019）

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摘要

Multiple dose administration of RPV LA was safe and well tolerated and was associated with prolonged suppression of viral replication in rectal explant tissue.

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关键词

long acting,rilpivirine,PrEP,rectum,vagina,prophylaxis

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