A novel compound AB-38b improves diabetes-associated cognitive decline in mice via activation of Nrf2/ARE pathway.

Ya-Jing Chen,Zhuang-Zhuang Tang,Lei Du,Yue Liu,Qian Lu,Teng-Fei Ma,Yao-Wu Liu

Brain Research Bulletin（2019）

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摘要

•AB-38b could improve the cognitive impairment of diabetic mice.•AB-38b could enhance the functions of glyoxylase 1.•Up-regulation of glyoxylase 1 resulted from activation of Nrf2/ARE pathway.

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关键词

AB,AGEs,ARE,CMC-Na,DACD,DM,FBG,γ-GCS,Glo-1,GSH,Nrf2,Res,ROS,STZ

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