Potential different impact of inhibition of thrombin function and thrombin generation rate for the growth of thrombi formed at site of endothelial injury under blood flow condition.

•Computer simulator implementing the function of platelet, coagulation, fibrinolysis and blood flow was developed.•There is negative relationship between size of thrombi formed by 30-seconds perfusion and the inhibition of thrombin function but not for thrombin generation rate.•Computer simulation may help to predict quantitative antithrombotic effects of various antithrombotic agents.