Distinct clinical features of predominant pre-synaptic and trans-synaptic nigrostriatal dysfunction in multiple system atrophy.

Ho-Sung Ryu,Minyoung Oh,Jungsu S Oh,Hyojeong Moon,Kye Won Park,Chaewon Lee,Sooyeoun You,Mi-Jung Kim,Young Jin Kim,Juyeon Kim,Kiju Kim,Jae Seung Kim,Sun Ju Chung

Journal of the Neurological Sciences（2019）

引用 4|浏览55

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摘要

•Brain [18F]FP-CIT- and [18F]FDG-PET is useful to understanding the features of MSA.•Parkinsonism is more severe in MSA with trans-synaptic nigrostriatal dysfunction.•Cerebellar ataxia is more severe in MSA with presynaptic nigrostriatal dysfunction.•MSA shows distinct features depending on the pattern of nigrostriatal dysfunction.

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关键词

Multiple system atrophy,Nigrostriatal integrity,Parkinsonism,Cerebellar ataxia,Orthostatic hypotension

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