Recreation of in-host acquired single nucleotide polymorphisms by CRISPR-Cas9 reveals an uncharacterised gene playing a role in Aspergillus fumigatus azole resistance via a non-cyp51A mediated resistance mechanism.

Eloise Ballard,Jakob Weber,Willem J G Melchers, Seshu Tammireddy,Phillip D Whitfield,Axel A Brakhage,Alistair J P Brown,Paul E Verweij,Adilia Warris

Fungal Genetics and Biology（2019）

引用 22|浏览15

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摘要

•New in-host acquired non-cyp51-mediated azole resistance mechanism in A. fumigatus.•167* mutation in AFUA_7G01960 leads to azole resistance and thermotolerance.•Azole resistance associated with decreased ergosterol content in fungal membrane.

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关键词

Aspergillus fumigatus,Azole resistance,CRISPR-Cas9,In-host adaptation,Ergosterol

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