Role of prophylactic radiotherapy in Chinese patients with primary testicular diffuse large B-cell lymphoma: a single retrospective study.

Purpose: To retrospectively evaluate the role of prophylactic radiotherapy (RT) and clinical prognostic factors for primary testicular diffuse large B-cell lymphomas (PT-DLBCL) patients in our cohort. Methods: Thirty patients diagnosed with PT-DLBCL between January 2007 and June 2017 were included in our study. Data came from electronic records and a histopathology electronic database. R and SPSS 23.00 were used for statistical analysis based on actual needs. Results: Median age at diagnosis of PT-DLBCL was 60 years (28-82). At the time of analysis, 6 patients (20.0%) suffered disease progression. The estimated 5-year risk of recurrence after treatment was 24.7%. In multivariate analysis, international prognostic index (IPI) was identified as the only independent prognostic factor for overall survival (OS) (p=0.025, HR 1.675, 95%CI: 1.065-2.634) and progression-free survival (PFS) (p=0.037, HR 1.669, 95%CI: 1.032-2.700). No correlation was established between prophylactic RT and superior OS or PFS, respectively (p=0.745, p=0.194). No significant correlation was established in either group between RT and OS (Low-risk: p=0.848; High-risk group: p=0.433) or PFS (Low-risk: p=0.170; High-risk: Fig 4H, p=0.871). Conclusions: Chinese PT-DLBCL patients had an earlier age of onset and the number of advanced stage patients occupied a larger proportion. Also, the effect of prophylactic RT was not as good as expected.