In situ visualization of peroxisomal peroxynitrite in the livers of mice with acute liver injury induced by carbon tetrachloride using a new two-photon fluorescent probe.

We developed a new two-photon fluorescent probe (PX-1) with high selectivity and sensitivity for detecting peroxisomal peroxynitrite. PX-1 was successfully applied to in situ imaging of peroxynitrite in the livers of mice with acute liver injury induced by carbon tetrachloride.