The neuropeptide receptor subunit RAMP1 constrains the innate immune response during acute pancreatitis in mice.

Leonie S Jochheim, Georgios Odysseos,Ana Hidalgo-Sastre,Suyang Zhong,Lina M Staufer, Markus Kroiss,Derya Kabacaoglu,Sebastian Lange,Thomas Engleitner,Daniel Hartmann,Norbert Hüser,Katja Steiger,Roland M Schmid,Bernhard Holzmann,Guido von Figura

Pancreatology（2019）

引用 6|浏览21

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摘要

Mice lacking RAMP1 showed increased inflammation, tissue edema, and pancreas injury particularly in the early phase of acute pancreatitis. This study highlights the essential role of CGRP for dampening the innate immune response in acute pancreatitis.

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关键词

Acute pancreatitis,CGRP,Innate immune response,RAMP1

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