Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein

Acta Neuropathologica Communications, pp. 1-19, 2019.

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Keywords:
MSA Prion Astrocytes α-Synuclein Proteinopathies

Abstract:

Glial cytoplasmic inclusions (GCIs) containing aggregated and hyperphosphorylated α-synuclein are the signature neuropathological hallmark of multiple system atrophy (MSA). Native α-synuclein can adopt a prion conformation that self-propagates and spreads throughout the brain ultimately resulting in neurodegeneration. A growing body of ev...More

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