MIF promoter polymorphisms are associated with epiretinal membrane but not retinal detachment with PVR in an american population.

Colleen M Cebulla,William Stevenson, Heather Van Law,Tyler Heisler-Taylor,Sumaya Hamadmad,Mohd Hussain Shah,Bongsu Kim,Frederick H Davidorf,Matthew Ohr,Michael Wells,Fatoumata Yanoga,Susie Chang,William Terrell,Daniel M Miller, Dino Klisovic,John B Allen,Niraj Shah, Elena Geraymovych,Ahmad B Tarabishy, Srinivas S Kondapalli,Beatrice Y Brewington,Andrea Inman,Demarcus Williams,Rania Kusibati, Jay Mathias, Yildiz Vedat,Soledad Fernandez,C Ellis Wisely,Robert Pilarski,Mohamed H Abdel-Rahman

Experimental Eye Research（2019）

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摘要

•MIF promoter polymorphisms rs5844572 and rs755622 are implicated in many inflammatory conditions.•Case-cohort genetic association study in the US from 2012 to 2018.•601 study subjects: RD (n = 180), RD with PVR (n = 120), ERM (n = 100) and 201 controls.•Significant association of rs755622 (C/C) and homozygous C7 haplotype with ERM.•No association was found between RD or PVR and the MIF polymorphisms.

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关键词

CI,ERM,MIF,OR,OVER-PVR Study Group,PVR,RD

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