High-DR CMOS Fluorescence Biosensor With Extended Counting ADC and Noise Cancellation.

Accurately resolving small fluorescence power variations in presence of noise and high-background tissue autofluorescence from deep brain structures with a fiber photometry system requires highly linear and sensitive photo detectors. This paper presents a high-dynamic range (DR) CMOS biosensor fusing a low-noise photosensing front-end with a high-precision extended counting analog-to-digital conve...