Discovery of a new autophagy inducer for A549 lung cancer cells.

Na Li, GuoJing Qu, JingNa Xue,Xiao Li,Xuan Zhao,YeHao Yan,DongFang Gao,Lu Zhang,Peng Wang,Ming Zhang,BaoXiang Zhao,JunYing Miao,ZhaoMin Lin

Bioorganic & Medicinal Chemistry（2019）

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摘要

•The activity of a series of fluorescent compounds was investigated.•Compounds 8 and 11 reduced the cell viability of A549 lung cancer cells.•Compound 8 inhibited the activity of mTOR.•Compounds 8 and 11 induced apoptosis and autophagy.•Compound 8 induced autophagy with intact autophagic flux.

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关键词

Small molecules,Autophagy,Apoptosis,A549 lung cancer cells,mTOR

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