Increasing Trans-Ethnic Diversity In Genome-Wide Association Meta-Analysis Of ADHD

Attention Deficit Hyperactivity Disorder(ADHD) is a highly heritable childhood behavioural disorder affecting 5% of school-age children and 2.5% of adults worldwide. Recently, the Psychiatric Genomics Consortium and iPSYCH successfully identified 12 independent loci significantly associated with ADHD in genome-wide meta-analysis of 20,183 ADHD cases and 35,191 controls of predominantly European ancestry (Demontis et al., in preparation). We expand upon this result by incorporating additional samples of non-European ancestry in order to advance genome-wide variant discovery, improve fine-mapping, and evaluate transferability of ADHD risk prediction across ancestries.