Jund Cardiac-Specific Overexpression Results In Larger Infarct

Introduction: Myocardial injury during short-term ischemia (I) and reperfusion (R) has become clinically important with the use of primary PCI as a first-line strategy in patients with acute coronary syndrome (ACS). The Jun family of activator protein 1 (AP-1) transcription factors (c-Jun, JunB, JunD) is involved in fundamental biological processes such as proliferation, apoptosis, tumor angiogenesis, and hypertrophy. Its member JunD is specifically expressed in the developing heart and cardiovascular system. Current evidence suggests a complex role for JunD in the adult heart. However, there is little in vivo evidence about how exactly JunD acts in the myocardium. In the present study we analyzed the role of junD in the heart using cardiac-specific JunD transgenic mouse line (cJunDTG) subjected to I/R. Hypothesis: Cardiac-specific overexpression of transcription factor JunD contributes to myocardial injury in a mouse model of cardiac ischemia and reperfusion. Methods: 8-12-week-old cJunDTG males and corr...