3D genome organization: a role for phase separation and loop extrusion?

•The 3D genome organization in plants and animals is very similar.•Distant regulatory elements and target genes interact through physical interactions.•Chromatin domains are formed based on transcription level and epigenetic landscape.•Phase separation, and maybe loop extrusion, underly the plant genome organization.•In plants loops can occur between active TADs that are separated by inactive TADs.