The role of immune correlates of protection on the pathway to licensure, policy decision and use of group B Streptococcus vaccines for maternal immunization: considerations from World Health Organization consultations
Vaccine(2019)
摘要
•There is a major public health need for GBS vaccines for maternal immunization.•Important obstacles lie in the way of a pivotal clinical efficacy trial for licensure.•A vaccine development pathway based on an immune correlate of protection is envisaged.•Key considerations and priority activities for success are presented, based on WHO consultations.
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关键词
Group B Streptococcus,Vaccines,Correlates of protection,Maternal immunization,Neonatal sepsis
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