Neurofilament light chain protein in neurodegenerative dementia: A systematic review and network meta-analysis

•42 trials including 8249 participants are enrolled in our meta-analysis.•A traditional and net meta-analysis was performed to test the diagnostic value of NfL.•NfL increases in all kinds of neurodegenerative disease compared to healthy controls.•NfL in CSF and blood differentiates neurodegenerative dementia from healthy controls.•NfL concentration is ranked among neurodegenerative dementia using cluster analysis.