PREDICTORS OF POSTOPERATIVE HEALTH-RELATED QUALITY OF LIFE (HRQOL): AN ANALYSIS FROM THE RAZOR TRIAL

You have accessJournal of UrologyBladder Cancer: Invasive II (MP32)1 Apr 2019MP32-20 PREDICTORS OF POSTOPERATIVE HEALTH-RELATED QUALITY OF LIFE (HRQOL): AN ANALYSIS FROM THE RAZOR TRIAL Vivek Venkatramani*, Maria Becerra, Isildinha Reis, Nachiketh Soodana-Prakash, Erik Castle, Mark Gonzalgo, Michael Woods, Robert Svatek, Alon Weizer, Badrinath Konety, Mathew Tollefson, Tracey Krupski, Norm Smith, Ahmad Shabsigh, Daniel Berocas, Marcus Quek, Atreya Dash, Adam Kibel, Raj Pruthi, Jeffrey Montgomery, Chrostopher Weight, David Sharp, Sam Chang, Michael Cookson, Gopal Gupta, Alex Gorbonos, Edward Uchio, Eila Skinner, Kerri kendrick, Joseph Smith, Ian Thompson, and Dipen Parekh Vivek Venkatramani*Vivek Venkatramani* More articles by this author , Maria BecerraMaria Becerra More articles by this author , Isildinha ReisIsildinha Reis More articles by this author , Nachiketh Soodana-PrakashNachiketh Soodana-Prakash More articles by this author , Erik CastleErik Castle More articles by this author , Mark GonzalgoMark Gonzalgo More articles by this author , Michael WoodsMichael Woods More articles by this author , Robert SvatekRobert Svatek More articles by this author , Alon WeizerAlon Weizer More articles by this author , Badrinath KonetyBadrinath Konety More articles by this author , Mathew TollefsonMathew Tollefson More articles by this author , Tracey KrupskiTracey Krupski More articles by this author , Norm SmithNorm Smith More articles by this author , Ahmad ShabsighAhmad Shabsigh More articles by this author , Daniel BerocasDaniel Berocas More articles by this author , Marcus QuekMarcus Quek More articles by this author , Atreya DashAtreya Dash More articles by this author , Adam KibelAdam Kibel More articles by this author , Raj PruthiRaj Pruthi More articles by this author , Jeffrey MontgomeryJeffrey Montgomery More articles by this author , Chrostopher WeightChrostopher Weight More articles by this author , David SharpDavid Sharp More articles by this author , Sam ChangSam Chang More articles by this author , Michael CooksonMichael Cookson More articles by this author , Gopal GuptaGopal Gupta More articles by this author , Alex GorbonosAlex Gorbonos More articles by this author , Edward UchioEdward Uchio More articles by this author , Eila SkinnerEila Skinner More articles by this author , Kerri kendrickKerri kendrick More articles by this author , Joseph SmithJoseph Smith More articles by this author , Ian ThompsonIan Thompson More articles by this author , and Dipen ParekhDipen Parekh More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000557548.51995.7aAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: Health-related quality of life (HRQoL) can be significantly affected following radical cystectomy (RC) and factors affecting it have not been well studied in this population. We evaluated predictors of QOL 3 months following RC in patients from the RAZOR trial; a multicenter, open-label non-inferiority phase III randomized trial comparing robot-assisted radical cystectomy (RARC) to open cystectomy (OC). METHODS: HRQoL was evaluated using the Functional Assessment of Cancer Therapy-Vanderbilt Cystectomy Index (FACT-VCI). All questionnaires were administered at baseline, 3- and 6- months (mo) postoperatively. A 3-mo postoperative time interval was chosen for this analysis. QOL comparisons between RARC and OC have been reported previously. Multiple regression analysis was conducted adjusting for key covariates to identify factors predicting FACT-VCI total score at 3-mo. RESULTS: BMI ≥30 [β estimate -10.80 (-20.03, -1.57), p=0.022] and worsening of independent activities of daily living (iADL) [β estimate -2.27 (-4.18, -0.36), p=0.021] at 3 months were associated with lower QOL (Table 1). Increasing age was associated with higher QOL [β estimate 0.49 (0.05, 0.94), p=0.031]. Surgical approach (RARC or OC), type of diversion, perioperative chemotherapy and major complications were not predictive of QOL at 3-mo. CONCLUSIONS: Postoperative HRQoL was not significantly affected by surgical approach, type of diversion, chemotherapy and major complications. However, age, BMI and iADL impacted QOL significantly. This provides important prospective data for patient counseling and reiterates the importance of studying QOL after major surgical procedures to reach a better understanding of how it can be affected, and potentially improved. Source of Funding: The RAZOR trial was supported by the National Institutes of Health (NIH) National Cancer Institute (NCI; grant number 5RO1CA155388). Miami, FL; Miami, FL; Miami, FL; Phoenix, AZ; Miami, FL; Chapel Hill, NC; San Antonio, TX; Ann Arbor, MI; Minneapolis, MN; Phoenix, AZ; Charlottesville, VA; Chicago, IL; Columbus, OH; Nashville, TN; Maywood, IL; Seattle, WA; Boston, MA; Chapel Hill, NC; Ann Arbor, MI; Minneapolis, MN; Columbus, OH; Nashville, TN; Norman, OK; Maywood, IL; Irvine, CA; Stanford, CA; San Antonio, TX; Nashville, TN; San Antonio, TX; Miami, FL© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e451-e452 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Vivek Venkatramani* More articles by this author Maria Becerra More articles by this author Isildinha Reis More articles by this author Nachiketh Soodana-Prakash More articles by this author Erik Castle More articles by this author Mark Gonzalgo More articles by this author Michael Woods More articles by this author Robert Svatek More articles by this author Alon Weizer More articles by this author Badrinath Konety More articles by this author Mathew Tollefson More articles by this author Tracey Krupski More articles by this author Norm Smith More articles by this author Ahmad Shabsigh More articles by this author Daniel Berocas More articles by this author Marcus Quek More articles by this author Atreya Dash More articles by this author Adam Kibel More articles by this author Raj Pruthi More articles by this author Jeffrey Montgomery More articles by this author Chrostopher Weight More articles by this author David Sharp More articles by this author Sam Chang More articles by this author Michael Cookson More articles by this author Gopal Gupta More articles by this author Alex Gorbonos More articles by this author Edward Uchio More articles by this author Eila Skinner More articles by this author Kerri kendrick More articles by this author Joseph Smith More articles by this author Ian Thompson More articles by this author Dipen Parekh More articles by this author Expand All Advertisement PDF downloadLoading ...