Core-shell lipid-polymer nanoparticles as a promising ocular drug delivery system to treat glaucoma

Yang Zhou,Aiping Fang,Fazhan Wang,Huili Li,Quansheng Jin,Lingjing Huang,Chunmei Fu,Jun Zeng,Zhaohui Jin,Xiangrong Song

Chinese Chemical Letters（2020）

引用 34|浏览12

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摘要

We prepared the core-shell lipid-polymer nanoparticles (LPNs) as the carriers of brinzolamide (Brz-LPNs) and investigated the potential of enhancing sustained drug release, corneal permeation and intraocular pressure (IOP) reduction of Brz-LPNs.

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关键词

Core-shell lipid-polymer nanoparticles,Ocular drug delivery system,Sustained release,Corneal permeation,Intraocular pressure

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