Interventions for secondary mitral regurgitation in patients with heart failure: A network meta-analysis of randomized controlled comparisons of surgery, medical therapy & transcatheter intervention

•Transcatheter leaflet repair was associated with significantly reduced 24-month mortality compared with medical therapy.•Valvular interventions were associated with lower rates of recurrent moderate-severe MR.•Sub-valvular interventions displayed superior trends regarding clinical and functional outcomes.