Depression in neurodegenerative diseases: Common mechanisms and current treatment options

Ciaran P.C. Galts,Luis E.B. Bettio, David C. Jewett,Charles C. Yang,Patricia S. Brocardo,Ana Lucia S. Rodrigues,Jonathan S. Thacker,Joana Gil-Mohapel

Neuroscience & Biobehavioral Reviews（2019）

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摘要

•Major depressive disorder is commonly associated with AD, PD, and HD.•Similar neurobiological changes contribute to the neuropathology of these diseases.•AD, PD, HD and MDD are associated with cerebral structural and functional changes.•Current antidepressants are not effective in treating MDD in AD, PD, and HD.•New antidepressants are warranted to improve quality of life in AD, PD, and HD.

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关键词

Alzheimer's disease,Clinical study,Depression,Huntington's disease,Neurodegeneration,Parkinson's disease,Preclinical study

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