“Platelet-rich plasma and its utility in medical dermatology - A systematic review”

Abstract The field of has seen numerous therapeutic innovations in the past decade with (PRP) recently garnering significant interest particularly in alopecia, acne scarring and rejuvenation. In other conditions of dermatology, such as chronic wounds and vitiligo, has been investigated but has received less attention. The objective of this literature review was to focus on conditions of medical and to consolidate the available evidence of for the practicing dermatologist. This review evaluates the literature up to October 31, 2018, and a search was conducted in the PubMed database for platelet-rich plasma or platelet releasate or platelet gel or platelet rich fibrin or PRP and dermatology or skin or cutaneous or or ulcer. Fourteen articles met the inclusion criteria for this review. In studies representing 1b-4 grades of evidence according to the Centre for Evidence-Based Medicine, Oxford, significantly improved wound healing in chronic diabetic ulcers, venous ulcers, pressure ulcers, leprosy ulcers, acute traumatic wounds and ulcers of multifactorial etiologies. Two studies also documented benefits of adjunctive in stable vitiligo. Platelet-rich warrants further investigation as it represents a potential therapeutic adjunct or alternative with a favorable side effect profile.