Supramolecular Vesicles Based on Water‐Soluble 2,6‐Helic[6]arene: High Affinity Binding, Stimuli Responsiveness and Delivery of Doxorubicin to Cancer Cells

Water-soluble 2,6-helic[6]arene was used to construct supramolecular vesicles via host-guest interaction. Water-soluble 2,6-helic[6]arene was discovered to be high affinity host for suitable biomarkers. Supramolecular vesicles were responsive to multiple stimuli types, including temperature, pH, Ca2+, CO2 bubbling and biomarker displacement. Supramolecular vesicles were used to load and deliver anti- tumor drug doxorubicin to HeLa cells in vitro.