LncRNA: Shedding light on mechanisms and opportunities in fibrosis and aging

•Fibrosis is universally observed in multiple aging-related diseases and progressions and is characterized by excess accumulation of the extracellular matrix.•LncRNAs have been identified to exert both promotive and inhibitory effects on the multifaceted processes of fibrosis.•LncRNAs are involved in fibrosis in various organs, including the liver, heart, lung, and kidney.•LncRNAs have become promising targets for anti-fibrosis therapies.