Metal-based redox-responsive MRI contrast agents

Sara M. Pinto,Vanessa Tomé,Mário J.F. Calvete,M. Margarida C.A. Castro,Éva Tóth,Carlos F.G.C. Geraldes

Coordination Chemistry Reviews（2019）

引用 56|浏览47

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摘要

•Metal-based complexes can provide relaxation and paraCEST redox responsive probes.•Some ligand-based and metal-based T1 and paraCEST redox probes work in small animals.•Mn-based nanoparticles - have a strong redox-active relaxation response in animals.•Ratiometric methods can provide quantitative redox evaluation of cells in vitro.

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关键词

MRI contrast agents,Metal chelates,Inorganic nanoparticles,Redox responsive probes,Hypoxia probes,Relaxation agents,ParaCEST agents

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