Historical Trends in Kawasaki Disease over Three Decades in a Single Institution

Purpose: Kawasaki disease (KD) awareness and therapy have evolved since its description in 1967. We explored historical trends since 1984 in patients (pts) treated for KD at a single institution. Methods: Inclusion criteria were 1) first episode of KD, and 2) treated with IVIG within 3 weeks of illness onset. Exclusion criteria were 1) evaluation solely for a second opinion, and 2) presence of congenital heart disease. We reviewed age at diagnosis, sex, race, presence of complete vs. incomplete (fever + u003c4 clinical criteria), days of fever at initial IVIG treatment, and incidence of retreatment. Changes in pt characteristics over time were evaluated using tests of trends. Results: Of 1739 pts, 1133 met eligibility criteria. Race included 61% White, 10% Black, 11% Asian: 6% other, and 12% unknown. At diagnosis, 16% were age u003c1 years (yrs), 58% were 1u003c5 yrs, 24% were 5u003c12 yrs, and 2% were ≥12 yrs. The median age at fever onset was 3 yrs and has not changed significantly over time. Male to female ratio was 5...