Study of serum microRNA19a and microRNA223 as potential biomarkers for early diagnosis of hepatitis C virus-related hepatocellular carcinoma

Fatma A. Fathy.Elmougy,Reham A. Mohamed,Mona M. Hassan, Suzan M. Elsheikh,Raghda N. Marzban, Fatma-elzahraa M. Ahmed,Rady E. Elaraby

Gene Reports（2019）

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摘要

•MiRNAs are able to bind complementary sequences of several target mRNAs to induce their degradation or translational repression.,MiRNA19a and miRNA223 were hepato-specific miRNA•Regulation of these miRNAs in HCC versus non-tumor liver this may suggests their role in hepatocarcinogenesis, AFP-L3 assay was found to show clinical value for early HCC diagnosis even at low AFP levels.•Current data suggest significant decrease in miRNA223 in serum of HCC patients and significant increase in miRNA19a in serum of HCC patients.

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HCC,RNA,(3′-UTR),HCV,miRNA,AFPL3,AFP,qRT-PCR,PCR,EASL,CLD,(HBV),HBsAg,(HBc-Ab),PTEN,SOX4,APAF1,PAK6,CT,ELISA,HRP,TMB,ALT,AST,ALP,AUC,ROC,FC

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