Targets, Treatments, and Outcomes Updates in Diabetic Stroke

Goal: Due to multiple failures to translate basic research, the need for novel therapeutic targets and strategies is still urgent to save a larger number of the stroke patients' population and to reduce the toxicity of the current stroke therapy. Method: We summarize the most recent, within past 5 years, basic and clinical diabetic stroke research findings. Findings: We aim to examine the most current understanding of stroke and neurovascular unit integrity, especially in presence of hyperglycemia and/or diabetes mellitus. From there, we are comparing the meaningful findings that aim at treating diabetic stroke to see where they differ, where they succeed, and where they open questions for new therapeutic strategies. Conclusion: The need for more clinically effective neuroprotective strategies is still mismatched with the bench side findings.