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Development of a Scalable Synthesis for the Potent Kinase Inhibitor BMS-986236; 1-(5-(4-(3-hydroxy-3-methylbutyl)-1h-1,2,3-triazol-1-yl)-4-(isopropylami No)pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine-5-carbonitrile

Pirama Nayagam Arunachalam,Prakasam Kuppusamy,Sivakumar Ganesan,Suresh Krishnamoorthy,Roshan Y. Nimje,Lokesh Babu Jarugu,Nanjundaswamy Kanikahalli Chikkananjaiah,China Anki Reddy,Prakash Anjanappa,Murali Botlagunta,Sridhar Vanteru,Nageswararao Maddala,Muniyappa Shankar,Satheesh Nair,John Hynes,Joseph B. Santella,Percy H. Carter,Richard Rampulla,Muthalagu Vetrichelvan,Anuradha Gupta,Arun Kumar Gupta,Arvind Mathur

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2019）

Cited 8|Views40
Key words
kinase inhibitor,scalable synthesis,DSC studies,azide,triazole,1H-pyrazolor[3,4-b]pyridine derivative
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