Synthesis and anticancer activity evaluation of novel oxacalix[2]arene[2]pyrimidine derivatives
Medicinal Chemistry Research(2019)
摘要
A series of novel oxacalix[2]arene[2]pyrimidine derivatives were synthesized, and their antitumor activities against HeLa, MCF7, HepG2, and A549 human cancer cell lines were evaluated using an MTT assay. Some of the synthesized compounds exhibited considerable anti-proliferative activity against the human cancer cell lines. Compound 5l , which contains an ethanolamine moiety, exhibited the strongest inhibitory activity against HepG2 with an IC 50 value of 12.37 μM. Moreover, a cell apoptosis assay indicated that the anti-proliferative activity of 5l might be attributed to its induction of apoptosis. Our report highlights the potential anticancer efficacy of novel oxacalix[2]arene[2]pyrimidines.
更多查看译文
关键词
Oxacalix[2]arene[2]pyrimidine, Ethanolamine, Anticancer, Apoptosis
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要