Disruption Of Myocardial Metabolism In Multiple Generations Of Mice Induced By Maternal Nutrient Overload
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY(2019)
摘要
Increased risk for cardiovascular disease is observed in the offspring of obese mothers, but its underlying mechanisms and heritability remain unknown. Based upon our observation that diet-induced obesity damages oocyte mitochondria and impairs mitophagy, we hypothesized that maternal mitochondrial
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关键词
myocardial metabolism,mice
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