COMPARISON OF THE SAFETY OF CELECOXIB, IBUPROFEN, AND NAPROXEN IN PATIENTS WITHOUT ESTABLISHED CARDIOVASCULAR DISEASE

Grant W. Reed,Haris Riaz, Quiqing Wang,Kathy Wolski,Lisa Wisniewski,Venu Menon,A. Lincoff,Steven Nissen

Journal of the American College of Cardiology（2019）

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摘要

Evidence on the safety of non-steroidal anti-inflammatory drugs (NSAIDs) in the primary prevention population is limited.In this on-treatment analysis of the PRECISION trial, patients with NSAID-dependent arthritis and no established cardiovascular disease were randomized to celecoxib, ibuprofen,

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