Resultados de la vigilancia nacional de resistencia antimicrobiana en infecciones asociadas a la atención en salud en enterobacterias y Gram negativos no fermentadores, Colombia 2012-2014

Introduction. From the third quarter of 2012 the National System monitoring antimicrobial resistance in Associated Infection Health Care in order to meet this problem in our country was implemented. Objective. To present the results of the National Surveillance System, describing the resistance profiles and laboratory surveillance. Materials and methods. A retrospective descriptive study framed in the National System for Public Health Surveillance -SIVIGILA since the third quarter of 2012 to December 2014, from information databases Whonet notified by generating primary data units and the results of surveillance phenotypic and genotypic laboratory isolates carbapenemases in 1,642 (927 Enterobacteriaceae, Pseudomonas spp 614., and 101 Acinetobacter spp.). Results. E. coli showed significant increase in resistance to third-generation cephalosporins resistance reaching 26.3% and 22.5% ICU hospitalization. K . pneumoniae showed an increase in resistance to ertapenem reaching 14.6% in ICU. A. baumannii in carbapenem resistance exceeded 50% in ICU, whereas P. aeruginosa lower (38.8%) percentages presented. The most frequent were KPC carbapenemases in Enterobacteriaceae (n = 574), followed by NDM (n = 57); VIM in P. aeruginosa (n = 229) and KPC (n = 114) A. baumannii and OXA-23 (n = 87). several co-productions were identified KPC + VIM being the most common in Pseudomonas spp. and Enterobacteriaceae. Conclusion. The information obtained from the national surveillance system has revealed antimicrobial resistance profiles and carbapenem resistance mechanisms that are circulating in health institutions.