AB036. P-04. The upregulation of Oct4 in acidic extracellular pH is associated with gemcitabine resistance in cholangiocarcinoma cell lines

Background: Cholangiocarcinoma (CCA), although is an uncommon liver cancer originating from bile duct epithelial cells, is one of the top 10 most fatal cancers. Chemoresistance is an unmet need always found in CCA patients. Tumor microenvironment conditions such as hypoxia, nutrient starvation and acidic extracellular pH play critical roles in cancer progression. However, the role of acidic extracellular pH in chemoresistance in CCA has not been studied.