Discovery Of Novel Titin (Ttn) Gene Truncating Mutations Among A Consecutive Cohort Of Patients Presenting With Idiopathic Dilated Cardiomyopathy (Idc)

Jeffrey L. Anderson,Victoria Jacobs,G. Bryce Christensen,Helaman Escobar,Benjamin Horne,Stacey Knight,Kia Afshar,Virginia B. Hebl,Kirk Knowlton,J. Muhlestein,John Carlquist,Lincoln D. Nadauld

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY（2019）

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摘要

IDC is known to have a strong genetic predisposition, with a large number of pathogenic mutations in multiple genes now reported. However, there remains a large heritability gap, suggesting an opportunity for additional discovery. TTN mutations are of interest because of their common and consistent

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dilated cardiomyopathy,novel titin,mutations,ttn,gene

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