CROTONOBETAINE IS A PROATHEROGENIC GUT MICROBIOTA METABOLITE OF L-CARNITINE

Robert Koeth,Miranda Culley,Zeneng Wang,Ina Nemet,Jennifer Kirsop,Elin Org,Jennifer Buffa,Xinmin Li,Bruce Levison,David Bartlett,Xiaoming Fu,Yuping Wu,Lin Li,Jonathan Smith,Joseph DiDonato, Jake Lusis,Wai Hong Tang,Stanley L. Hazen

Journal of the American College of Cardiology（2019）

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摘要

L -Carnitine, a nutrient in red meat, accelerates atherosclerosis in a gut microbiota-dependent pathway by the formation of trimethylamine- N -oxide (TMAO). We now show that a novel compound, crotonobetaine (crotono), identified in a metabolomics study, is a product of L -carnitine gut microbial

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