Infant Growth As An Effect Modifier Of Genetic-Lipid Associations: Evidence From A Chilean Infancy Cohort
Circulation(2018)
摘要
Background: The postnatal period can function as a window of time for metabolic programming. As evidence from human observational studies is scarce, we examined the role of postnatal weight, length (linear growth), and weight-for-length (WFL) growth trajectories as effect modifiers of established single nucleotide polymorphism (SNP) associations on lipid levels in a cohort of adolescents from the Santiago Longitudinal Study (SLS) (n=484). Methods: Growth trajectories were characterized via two different approaches: nonlinear mixed effects model (SITAR) and a latent growth mixture model (LGMM). We assessed gene-environment interaction in an additive model within: 1) SITAR including product terms that accurately reflects the trichotomous genetic term, and 2) LGMM using stratified SNP-lipid associations by latent growth patterns. Bonferroni-corrected significant findings are reported. Results: SITAR models did not reveal any evidence of gene-environment interaction. In contrast, given three LGMM patterns of ...
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关键词
Lipids, Children, Genetics
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